Reaction Details Report a problem with these data
Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50086591
Substrate
n/a
Meas. Tech.
ChEMBL_1477109 (CHEMBL3428276)
Ki
320±n/a nM
Citation
Hoang, HN; Song, K; Hill, TA; Derksen, DR; Edmonds, DJ; Kok, WM; Limberakis, C; Liras, S; Loria, PM; Mascitti, V; Mathiowetz, AM; Mitchell, JM; Piotrowski, DW; Price, DA; Stanton, RV; Suen, JY; Withka, JM; Griffith, DA; Fairlie, DP Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists. J Med Chem 58:4080-5 (2015) [PubMed] Article
More Info.:
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Human
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
Inhibitor
Name:
BDBM50086591
Synonyms:
CHEMBL3426246
Type:
Small organic molecule
Emp. Form.:
C74H98FN15O17
Mol. Mass.:
1488.6586
SMILES:
[H][C@]1(NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)C(=O)N[C@@H](CCCc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O |r|