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Target
Integrase
Ligand
BDBM50476348
Substrate
n/a
Meas. Tech.
ChEMBL_435306 (CHEMBL903664)
IC50
11000±n/a nM
Citation
 Patil, S; Kamath, S; Sanchez, T; Neamati, N; Schinazi, RF; Buolamwini, JK Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors. Bioorg Med Chem 15:1212-28 (2007) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus type 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50476348
Synonyms:
GSK-S-1360 | GW-810781 | Gw810781 | S 1360 | S-1360
Type:
Small organic molecule
Emp. Form.:
C16H12FN3O3
Mol. Mass.:
313.2832
SMILES:
O\C(=C/C(=O)c1ccc(Cc2ccc(F)cc2)o1)c1nc[nH]n1
Structure:
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