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Target
Cyclin-dependent kinase 11B
Ligand
BDBM50528539
Substrate
n/a
Meas. Tech.
ChEMBL_1922873 (CHEMBL4425829)
Kd
370±n/a nM
Citation
 Wang, Z; Bian, H; Bartual, SG; Du, W; Luo, J; Zhao, H; Zhang, S; Mo, C; Zhou, Y; Xu, Y; Tu, Z; Ren, X; Lu, X; Brekken, RA; Yao, L; Bullock, AN; Su, J; Ding, K Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem 59:5911-6 (2016) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 11B
Synonyms:
2.7.11.22 | CD11B_HUMAN | CDC2L1 | CDK11 | CDK11B | CLK-1 | Cell division cycle 2-like protein kinase 1 | Cell division protein kinase 11B | Cyclin-dependent kinase | Cyclin-dependent kinase 11 (CDK11) | Cyclin-dependent kinase 11B | Galactosyltransferase-associated protein kinase p58/GTA | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLREA | PK58 | p58 CLK-1
Type:
Protein
Mol. Mass.:
92685.77
Organism:
Homo sapiens (Human)
Description:
P21127
Residue:
795
Sequence:
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
  
Inhibitor
Name:
BDBM50528539
Synonyms:
CHEMBL4553037
Type:
Small organic molecule
Emp. Form.:
C26H23F3N6O
Mol. Mass.:
492.4956
SMILES:
C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Structure:
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