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Target
Transcriptional enhancer factor TEF-4
Ligand
BDBM50604885
Substrate
n/a
Meas. Tech.
ChEMBL_2249579 (CHEMBL5163789)
Ki
>400000±n/a nM
Citation
 Feng, X; Yan, Z; Zhou, F; Lou, J; Lyu, X; Ren, X; Zeng, Z; Liu, C; Zhang, S; Zhu, D; Huang, H; Yang, J; Zhao, Y Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells. Eur J Med Chem 236:0 (2022) [PubMed] 
Target
Name:
Transcriptional enhancer factor TEF-4
Synonyms:
TEA domain family member 2 | TEAD-2 | TEAD2 | TEAD2_HUMAN | TEF4 | Transcriptional enhancer factor TEF-4
Type:
PROTEIN
Mol. Mass.:
49241.42
Organism:
Homo sapiens
Description:
ChEMBL_119051
Residue:
447
Sequence:
MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD
  
Inhibitor
Name:
BDBM50604885
Synonyms:
CHEMBL5177177
Type:
Small organic molecule
Emp. Form.:
C27H25FN4O
Mol. Mass.:
440.512
SMILES:
Fc1cccc(c1)-c1ccc2c(N3CCN(CC3)C(=O)C=C)n(Cc3ccccc3)nc2c1
Structure:
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