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Found 2406 with Last Name = 'lou' and Initial = 'j'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50605126(CHEMBL5187340)
Affinity DataKi:  0.00200nMAssay Description:Displacement of 5-FAM labeled PDI peptide from MDM2 (1 to 118 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50498230(CHEMBL3577576)
Affinity DataKi:  0.00300nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50498229(CHEMBL3577575)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of wild type HIV1 proteaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243536(CHEMBL4062749)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Yancheng Teachers University

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | US11420968, Example ABT-199 | Venetoclax)
Affinity DataKi: <0.0100nMAssay Description:Displacement of fluorescent-labeled BID-BH3 peptide from human BCL-2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant by fluo...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243536(CHEMBL4062749)
Affinity DataKi:  0.0100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0150nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  0.0160nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471254(CHEMBL308234)
Affinity DataKi:  0.0230nMAssay Description:Stimulation of alkaline phosphatase activity in human endometrial Ishikawa cells with 1 nM E2 estradiolMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471256(CHEMBL291808)
Affinity DataKi:  0.0280nMAssay Description:Apparent binding affinity against estradiol-stimulated T-47D cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311170((S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(t...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311182((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311157((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifl...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311155((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-cyanop...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311180((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311158((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifl...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0420nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0470nMAssay Description:Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311268((S)-1-((2′,4-bis(difluoromethyl)-[2,4′...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311176((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311179((S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(d...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311189((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311160((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-chloro...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0690nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 2.5%DMFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311181((S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(t...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311264((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311261((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-6-...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311178((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0760nMAssay Description:Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311165((S)-methyl (4-(4-((2-amino-4-methylpentyl)oxy)-3-(...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604135(CHEMBL5198877)
Affinity DataKi:  0.0800nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311159((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-methyl...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311177((S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-cy...)
Affinity DataKi:  0.0900nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604134(CHEMBL5187778)
Affinity DataKi:  0.0900nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM50471255(Acolbifene | EM-652 | SCH-57068)
Affinity DataKi:  0.0900nMAssay Description:Apparent binding affinity against estradiol-stimulated ZR-75-1-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243589(CHEMBL4095223)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243625(CHEMBL4094098)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243589(CHEMBL4095223)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243545(CHEMBL4078689)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243608(CHEMBL4100882)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243625(CHEMBL4094098)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243608(CHEMBL4100882)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243545(CHEMBL4078689)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50604141(CHEMBL5188433)
Affinity DataKi:  0.110nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311380((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Affinity DataKi:  0.110nMAssay Description:Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.113nMAssay Description:Apparent inhibition constant for estrogen receptor in Human Breast cancer cytosol in 2.5%DMFMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Le Centre Hospitalier Universitaire De Qu£Bec

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataKi:  0.120nMAssay Description:Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanolMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243588(CHEMBL4067800)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50243626(CHEMBL4089821)
Affinity DataKi:  0.126nMAssay Description:Displacement of [3H]CP55940 from recombinant human CB1 receptor expressed in beta-galactosidase expressing CHOK1 cell membranes after 60 mins by scin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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