Reaction Details Report a problem with these data
Target
Progesterone receptor
Ligand
BDBM50121163
Substrate
n/a
Meas. Tech.
ChEMBL_29969 (CHEMBL875251)
IC50
6.6±n/a nM
Citation
Collins, MA; Hudak, V; Bender, R; Fensome, A; Zhang, P; Miller, L; Winneker, RC; Zhang, Z; Zhu, Y; Cohen, J; Unwalla, RJ; Wrobel, J Novel pyrrole-containing progesterone receptor modulators. Bioorg Med Chem Lett 14:2185-9 (2004) [PubMed] Article
More Info.:
Target
Name:
Progesterone receptor
Synonyms:
NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone
Type:
Protein
Mol. Mass.:
98979.52
Organism:
Homo sapiens (Human)
Description:
P06401
Residue:
933
Sequence:
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Inhibitor
Name:
BDBM50121163
Synonyms:
3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-5'-yl)benzonitrile | 3-[2'-oxospiro[cyclohexane-1,3'-(2',3'-dihydro-1'H-indole)]-5-yl]benzonitrile | CHEMBL308938
Type:
Small organic molecule
Emp. Form.:
C20H18N2O
Mol. Mass.:
302.3697
SMILES:
O=C1Nc2ccc(cc2C11CCCCC1)-c1cccc(c1)C#N