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Found 130 with Last Name = 'bender' and Initial = 'r'
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataIC50:  0.100nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.720nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470071(CHEMBL150507)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470073(CHEMBL153188)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  1.5nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470063(CHEMBL152957)
Affinity DataIC50:  1.80nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470065(CHEMBL348472)
Affinity DataIC50:  2.20nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470068(CHEMBL152958)
Affinity DataIC50:  2.30nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470075(CHEMBL440731)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470061(CHEMBL345528)
Affinity DataIC50:  3.20nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099585(1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyph...)
Affinity DataIC50:  3.70nMAssay Description:In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiolMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory concentration against [3H]-17-beta-estradiol binding to human estrogen receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50040439(2,4-Dimethyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50:  5.20nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121163(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Affinity DataIC50:  6.60nMAssay Description:Ability to block progesterone induced alkaline phosphatase activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118695(3-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  8nMAssay Description:Ability to block progesterone induced alkaline phosphatase activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118694(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121165(3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-5...)
Affinity DataIC50:  13nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470067(CHEMBL153472)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121167(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)
Affinity DataIC50:  14nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118696(5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121163(3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indo...)
Affinity DataIC50:  15nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121172(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-...)
Affinity DataIC50:  20nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121176(3-(2'-oxo-1',2'-dihydrospiro[cyclopentane-1,3'-ind...)
Affinity DataIC50:  21nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470062(CHEMBL346420)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099585(1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-2-(4-hydroxyph...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50144449(5-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  23nMAssay Description:Ability to block progesterone induced alkaline phosphatase activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470066(CHEMBL155163)
Affinity DataIC50:  24nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470069(CHEMBL347320)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099586(2-(4-Hydroxy-phenyl)-3-methyl-1-(6-pyrrolidin-1-yl...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121164(3-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-b...)
Affinity DataIC50:  27nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121157(5-(3-Fluoro-5-nitro-phenyl)-3,3-dimethyl-1,3-dihyd...)
Affinity DataIC50:  27nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121178(5-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-t...)
Affinity DataIC50:  28nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121161(5-(3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-4...)
Affinity DataIC50:  29nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121183(5-(3-Chloro-5-fluoro-phenyl)-3,3-dimethyl-1,3-dihy...)
Affinity DataIC50:  29nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121184(3,3-Dimethyl-5-(5-nitro-thiophen-2-yl)-1,3-dihydro...)
Affinity DataIC50:  29nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118700(6-(3-Chloro-phenyl)-4,4-dimethyl-1,4-dihydro-benzo...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121168(3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-...)
Affinity DataIC50:  31nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121158(5'-(3-chlorophenyl)spiro[cyclopentane-1,3'-indol]-...)
Affinity DataIC50:  32nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM82258(CAS_114798-26-4 | Losartan | NSC_3961)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50144436(5'-(5-nitro-1H-2-pyrrolyl)spiro[cyclohexane-1,3'-(...)
Affinity DataIC50:  36nMAssay Description:Ability to block progesterone induced alkaline phosphatase activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121166(5'-(3-nitrophenyl)spiro[cyclopentane-1,3'-indol]-2...)
Affinity DataIC50:  38nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099587(2-(4-Hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory concentration against [3H]-17-beta-estradiol binding to human estrogen receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50144433(4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]...)
Affinity DataIC50:  41nMAssay Description:Ability to block progesterone induced alkaline phosphatase activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Affinity DataIC50:  41nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  43nMAssay Description:In vitro inhibitory concentration against [3H]-17-beta-estradiol binding to human estrogen receptor 2More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor A/B(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50470077(CHEMBL433930)
Affinity DataIC50:  49nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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