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Target
Estrogen receptor [298-554]
Ligand
BDBM521261
Substrate
n/a
Meas. Tech.
Biochemical Antagonist Activity on Wild Type (WT) and Mutants
IC50
1.000±n/a nM
Citation
 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof US Patent  US11149031 Publication Date 10/19/2021 
Target
Name:
Estrogen receptor [298-554]
Synonyms:
ESR | ESR1 | ESR1_HUMAN | Estrogen Receptor alpha (aa 298-554) | NR3A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29227.65
Organism:
Homo sapiens (Human)
Description:
P03372[298-554]
Residue:
256
Sequence:
KRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTS
  
Inhibitor
Name:
BDBM521261
Synonyms:
6-(2,4- dichlorophenyl)- 5-[4-[[(3S)-1- (3- fluoropropyl)pyr- rolidin-3- yl]amino]phenyl]- 8,9-dihydro- 7H- benzo[7]annulen- 2-ol | US11149031, Example 85
Type:
Small organic molecule
Emp. Form.:
C30H31Cl2FN2O
Mol. Mass.:
525.484
SMILES:
Oc1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(N[C@H]3CCN(CCCF)C3)cc2)c1 |r,c:18|
Structure:
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