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Found 2648 with Last Name = 'schio' and Initial = 'l'
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataKi:  990nMAssay Description:Inhibition of human recombinant CYP3A4 in liver microsomes by mechanism based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM21363(12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triaza...)
Affinity DataKi:  2.47E+3nMAssay Description:Inhibition of human recombinant CYP3A4 in liver microsomes by mechanism based inhibition assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Sanofi Research Center

Curated by ChEMBL
LigandPNGBDBM50134434(CHEMBL3746046)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Sanofi Research Center

Curated by ChEMBL
LigandPNGBDBM50134433(CHEMBL3745968)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Sanofi Research Center

Curated by ChEMBL
LigandPNGBDBM50134429(CHEMBL3746964)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Sanofi Research Center

Curated by ChEMBL
LigandPNGBDBM50134432(CHEMBL3747036)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521421(6-(2,4- dichlorophenyl)- 1-fluoro-5-[6- [(3S)-1-(3...)
Affinity DataIC50:  0.400nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521255(3-(6-ethoxy-2- fluoro-3- pyridyl)-4-[6- [(3S)-1-(3...)
Affinity DataIC50:  0.5nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521262(6-(6-ethoxy-2- fluoro-3- pyridyl)-5-[4- [[(3S)-1-(...)
Affinity DataIC50:  0.5nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50059435(CHEMBL3393498)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of poly-histidine tagged full length recombinant aurora A (unknown origin) assessed as phosphorylation of NuMA-histidine substrate by scin...More data for this Ligand-Target Pair
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521413(6-(2-fluoro-4- methyl-phenyl)- 5-[6-[(3S)-1-(3- fl...)
Affinity DataIC50:  0.600nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521384(4-(6-ethoxy-2- fluoro-3- pyridyl)-5-[6- [(3S)-1-(3...)
Affinity DataIC50:  0.600nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Sanofi Research Center

Curated by ChEMBL
LigandPNGBDBM50134428(CHEMBL3746007)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521382(4-(2-chloro-4- methyl-phenyl)- 5-[6-[(3S)-1-(3- fl...)
Affinity DataIC50:  0.700nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521428(6-(6-ethoxy-2- fluoro-3- pyridyl)-1- fluoro-5-[6- ...)
Affinity DataIC50:  0.700nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50004205(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263706(6-(2- chloro-4- ethoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Affinity DataIC50:  0.800nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)
Affinity DataIC50:  1nMAssay Description:Inhibition of aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521261(6-(2,4- dichlorophenyl)- 5-[4-[[(3S)-1- (3- fluoro...)
Affinity DataIC50:  1nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Sanofi

Curated by ChEMBL
LigandPNGBDBM47224(US9073917, 2-inventive)
Affinity DataIC50:  1nMAssay Description:Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM47224(US9073917, 2-inventive)
Affinity DataIC50:  1nMAssay Description:The effect of the compounds of the invention on the activity of the enzyme PDE3 was evaluated by the company CEREP (Le bois I'Evęque, 86600 Celle...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM50447088(CHEMBL3112850)
Affinity DataIC50:  1nMAssay Description:This test is based on measuring the expression of the AKT protein phosphorylated on serine 473 (P-AKT-S473), in the PC3 human prostate carcinoma line...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50447088(CHEMBL3112850)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50447089(CHEMBL3112849)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal ploy-His-tagged human PI3Kbeta expressed in baculovirus-infected sf21 cells using PI(4,5)P2 as substrate after 15 mins by HT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263893(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263900(6-[2,3- difluoro-4- (1-piperidyl)- phenyl]-5- [4-[...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263911(US9714221, Example 207)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263860(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263892(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263709(6-(4- ethoxy-2- methyl- phenyl)-1- fluoro-5-[4- [(...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263712(6-(2,3- dihydro- 1,4- benzodioxin-6-yl)-5- [4-[(3S...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263774(US9714221, Example 108)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263775(US9714221, Example 109)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263719(6-(1,3- benzoxazol- 5-yl)-5-[4- [(3S)-1-(3- fluoro...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263737(6-(6- ethoxy-2- fluoro-3- pyridyl)-5- [4-[(3S)- 1-...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263743(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263748(US9714221, Example 82)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532762(CHEMBL4513820)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532763(CHEMBL4593634)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263847(6-(2,2-dimethylindolin-5-yl)-5-[4-[(3S)-1-(3-fluor...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263755(6-(2- chloro-4- methoxy- phenyl)-5- [4-[(3S)-1- (3...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263764(6-(2,2- dimethyl- 3H- benzo- furan-5-yl)-5- [4-[(3...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532756(CHEMBL4466644)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521334(5-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...)
Affinity DataIC50:  1nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532756(CHEMBL4466644)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532762(CHEMBL4513820)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Sanofi-Aventis Germany

Curated by ChEMBL
LigandPNGBDBM50532763(CHEMBL4593634)
Affinity DataIC50:  1nMAssay Description:Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521377(4-(2,2-dimethyl- 3H-benzofuran- 5-yl)-5-[4-[(3S)- ...)
Affinity DataIC50:  1nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [298-554](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM521378(5-[4-[(3S)-1-(3- fluoropropyl)pyr- rolidin-3- yl]o...)
Affinity DataIC50:  1nMAssay Description:Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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