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Target
Estrogen receptor [298-554,Y537S]
Ligand
BDBM521421
Substrate
n/a
Meas. Tech.
Biochemical Antagonist Activity on Wild Type (WT) and Mutants
IC50
3.00±n/a nM
Citation
 Bouaboula, M; Brollo, M; Certal, V; El-Ahmad, Y; Filoche-Romme, B; Halley, F; McCort, G; Schio, L; Tabart, M; Terrier, C; Thompson, F Substituted N-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof US Patent  US11149031 Publication Date 10/19/2021 
Target
Name:
Estrogen receptor [298-554,Y537S]
Synonyms:
ESR | ESR1 | ESR1_HUMAN | Estrogen Receptor alpha (aa 298-554, Y537S) | NR3A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29151.56
Organism:
Homo sapiens (Human)
Description:
P03372[298-554,Y537S]
Residue:
256
Sequence:
KRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRLHAPTS
  
Inhibitor
Name:
BDBM521421
Synonyms:
6-(2,4- dichlorophenyl)- 1-fluoro-5-[6- [(3S)-1-(3- fluoropropyl)pyr- rolidin-3-yl]oxy- 3-pyridyl]-8,9- dihydro-7H- benzo[7]annulen- 2-ol | US11149031, Example 245
Type:
Small organic molecule
Emp. Form.:
C29H28Cl2F2N2O2
Mol. Mass.:
545.448
SMILES:
Oc1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)nc2)c1F |r,c:18|
Structure:
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