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Target
Tyrosine-protein kinase Mer
Ligand
BDBM537536
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<20±n/a nM
Citation
 Allen, S; Boys, ML; Cook, A; Gaudino, J; Hinklin, RJ; Laird, E; McNulty, OT; Metcalf, AT; Newhouse, B; Robinson, JE Bicyclic fused pyridine compounds as inhibitors of TAM kinases US Patent  US11247990 Publication Date 2/15/2022 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM537536
Synonyms:
1-((1s,4s)-4-(3- chlorophenoxy)cyclohexyl)-N- methyl-3-(1-methyl-1H- pyrazol-4-yl)-1H- pyrazolo[4,3-c]pyridin-6- amine | US11247990, Example 361
Type:
Small organic molecule
Emp. Form.:
C23H25ClN6O
Mol. Mass.:
436.937
SMILES:
CNc1cc2n(nc(-c3cnn(C)c3)c2cn1)C1CC[C@@H](CC1)Oc1cccc(Cl)c1 |r,wU:20.26,(-3.78,-4.22,;-2.44,-4.99,;-1.11,-4.22,;-1.11,-2.68,;.23,-1.91,;.55,-.41,;2.08,-.25,;2.7,-1.65,;4.21,-1.97,;4.84,-3.38,;6.37,-3.22,;6.69,-1.71,;8.09,-1.09,;5.35,-.94,;1.56,-2.68,;1.56,-4.22,;.23,-4.99,;-.48,.74,;-.01,2.2,;-1.04,3.35,;-2.55,3.03,;-3.02,1.56,;-1.99,.42,;-3.58,4.17,;-5.08,3.85,;-6.11,4.99,;-7.62,4.67,;-8.09,3.21,;-7.06,2.06,;-7.54,.6,;-5.56,2.39,)|
Structure:
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