Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase receptor UFO
Ligand
BDBM537544
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<20±n/a nM
Citation
 Allen, S; Boys, ML; Cook, A; Gaudino, J; Hinklin, RJ; Laird, E; McNulty, OT; Metcalf, AT; Newhouse, B; Robinson, JE Bicyclic fused pyridine compounds as inhibitors of TAM kinases US Patent  US11247990 Publication Date 2/15/2022 
Target
Name:
Tyrosine-protein kinase receptor UFO
Synonyms:
AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN
Type:
Enzyme
Mol. Mass.:
98316.97
Organism:
Homo sapiens (Human)
Description:
P30530
Residue:
894
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
  
Inhibitor
Name:
BDBM537544
Synonyms:
2-(4-(1-((1s,4s)-4-(2,3- difluorophenoxy)cyclohexyl)- 6-(methylamino)-1H- pyrazolo[4,3-c]pyridin-3-yl)- 1H-pyrazol-1-yl)-2- methylpropanenitrile | US11247990, Example 369
Type:
Small organic molecule
Emp. Form.:
C26H27F2N7O
Mol. Mass.:
491.5357
SMILES:
CNc1cc2n(nc(-c3cnn(c3)C(C)(C)C#N)c2cn1)C1CC[C@@H](CC1)Oc1cccc(F)c1F |r,wD:24.30,(5.86,-1.28,;4.53,-.51,;3.2,-1.28,;1.86,-.51,;.53,-1.28,;-.93,-.8,;-1.84,-2.05,;-.93,-3.29,;-1.41,-4.76,;-.51,-6,;-1.41,-7.25,;-2.88,-6.77,;-2.88,-5.23,;-4.12,-7.68,;-5.03,-6.43,;-3.22,-8.93,;-5.37,-8.59,;-6.61,-9.49,;.53,-2.82,;1.86,-3.59,;3.2,-2.82,;-1.41,.66,;-2.92,.98,;-3.39,2.45,;-2.36,3.59,;-.86,3.27,;-.38,1.81,;-2.84,5.06,;-1.81,6.2,;-.3,5.88,;.73,7.02,;.25,8.49,;-1.25,8.81,;-1.73,10.27,;-2.28,7.67,;-3.79,7.99,)|
Structure:
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