Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM10992
Substrate
BDBM10990
Meas. Tech.
MAO A and MAO B Activity Measurements
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
6000±n/a nM
Citation
 Binda, C; Hubalek, F; Li, M; Herzig, Y; Sterling, J; Edmondson, DE; Mattevi, A Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J Med Chem 48:8148-54 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM10992
Synonyms:
rasagiline analog | (1R)-1-[methyl(prop-2-yn-1-yl)amino]-2,3-dihydro-1H-inden-4-yl N-ethyl-N-methylcarbamate | 4-(N-methyl-N-ethyl-carbamoyloxy)-N-methyl-N-propargyl-1(R)-aminoindan | R-M4CPAI
Type:
Small organic molecule
Emp. Form.:
C17H22N2O2
Mol. Mass.:
286.3688
SMILES:
CCN(C)C(=O)Oc1cccc2[C@@H](CCc12)N(C)CC#C |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10990
Synonyms:
3-amino-1-(2-aminophenyl)propan-1-one | Diaminopropiophenone | Kynuramine
Type:
Small organic molecule
Emp. Form.:
C9H12N2O
Mol. Mass.:
164.2044
SMILES:
NCCC(=O)c1ccccc1N
Structure:
Search PDB for entries with ligand similarity: