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Target
Heat shock protein HSP 90-beta
Ligand
BDBM20812
Substrate
BDBM10852
Meas. Tech.
Her-2 Degradation Assay
EC50
42±n/a nM
Citation
 Kasibhatla, SR; Hong, K; Biamonte, MA; Busch, DJ; Karjian, PL; Sensintaffar, JL; Kamal, A; Lough, RE; Brekken, J; Lundgren, K; Grecko, R; Timony, GA; Ran, Y; Mansfield, R; Fritz, LC; Ulm, E; Burrows, FJ; Boehm, MF Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity. J Med Chem 50:2767-78 (2007) [PubMed]  Article 
Target
Name:
Heat shock protein HSP 90-beta
Synonyms:
HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90)
Type:
Molecular Chaperone
Mol. Mass.:
83229.45
Organism:
Homo sapiens (Human)
Description:
P08238
Residue:
724
Sequence:
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAAVPDEIPPLEGDEDASRMEEVD
  
Inhibitor
Name:
BDBM20812
Synonyms:
2-amino-6-halopurine analogue, 34 | 6-chloro-9-[(3,4,5-trimethylpyridin-2-yl)methyl]-9H-purin-2-amine
Type:
Small organic molecule
Emp. Form.:
C14H15ClN6
Mol. Mass.:
302.762
SMILES:
Cc1cnc(Cn2cnc3c(Cl)nc(N)nc23)c(C)c1C
Structure:
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Substrate