Reaction Details Report a problem with these data
Target
Phosphoribosylglycinamide formyltransferase
Ligand
BDBM22588
Substrate
BDBM22589
Meas. Tech.
GAR Tfase Activity Assay
pH
7.5±n/a
Temperature
299.15±n/a K
Ki
>100000±n/a nM
Citation
 Xu, L; Chong, Y; Hwang, I; D'Onofrio, A; Amore, K; Beardsley, GP; Li, C; Olson, AJ; Boger, DL; Wilson, IA Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem 282:13033-46 (2007) [PubMed]  Article 
Target
Name:
Phosphoribosylglycinamide formyltransferase
Synonyms:
5 -phosphoribosylglycinamide transformylase | GAR Tfase | GART | Glycinamide Ribonucleotide Transformylase | PUR3_ECOLI | Phosphoribosylglycinamide formyltransferase | purN
Type:
Enzyme
Mol. Mass.:
23233.97
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
212
Sequence:
MNIVVLISGNGSNLQAIIDACKTNKIKGTVRAVFSNKADAFGLERARQAGIATHTLIASAFDSREAYDRELIHEIDMYAPDVVVLAGFMRILSPAFVSHYAGRLLNIHPSLLPKYPGLHTHRQALENGDEEHGTSVHFVTDELDGGPVILQAKVPVFAGDSEDDITARVQTQEHAIYPLVISWFADGRLKMHENAAWLDGQRLPPQGYAADE
  
Inhibitor
Name:
BDBM22588
Synonyms:
Nucleotide, 3 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2,2,4-trioxo-1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadiazin-7-yl)oxolan-2-yl]methoxy}phosphonic acid
Type:
Nucleoside or nucleotide
Emp. Form.:
C9H13N4O10PS
Mol. Mass.:
400.259
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c1NS(=O)(=O)NC2=O |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22589
Synonyms:
GAR | Glycineamideribotide | glycineamide ribonucleotide | {[(2R,3S,4R,5R)-5-(2-aminoacetamido)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Type:
Nucleoside or nucleotide
Emp. Form.:
C7H15N2O8P
Mol. Mass.:
286.1764
SMILES:
NCC(=O)N[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Structure:
Search PDB for entries with ligand similarity: