Compile Data Set for Download or QSAR
maximum 50k data
Found 173 with Last Name = 'wilson' and Initial = 'ia'
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24693(10-CF3CO-DDACTHF (5) | 10-CF3CO-DDACTHF, 2 | 2-({4...)
Affinity DataKi:  30nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24693(10-CF3CO-DDACTHF (5) | 10-CF3CO-DDACTHF, 2 | 2-({4...)
Affinity DataKi:  30nM ΔG°:  -43.1kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24693(10-CF3CO-DDACTHF (5) | 10-CF3CO-DDACTHF, 2 | 2-({4...)
Affinity DataKi:  30nMAssay Description:Inhibition of human recombinant GAR TfaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  60nM ΔG°:  -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50005518((S)-2-(4-(2-((R)-2-amino-4-oxo-1,4,5,6,7,8-hexahyd...)
Affinity DataKi:  60nMAssay Description:Inhibition of human recombinant GAR TfaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  60nM ΔG°:  -41.4kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoribosylglycinamide formyltransferase(Escherichia coli (strain K12))
The Scripps Research Institute

LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi:  100nM ΔG°:  -40.1kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50186739((2S)-2-(4-(6-(2,4-diamino-6-oxo-1,6-dihydropyrimid...)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant GAR TfaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22585(1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...)
Affinity DataKi:  130nM ΔG°:  -38.9kJ/molepH: 7.4 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22588(Nucleotide, 3 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...)
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50158378(5-(5-sulfamoyl-naphthalen-2-ylazo)-naphthalene-1-s...)
Affinity DataKi:  154nMAssay Description:Inhibition of human AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24686(10-thiomethyl-DDACTHF, 10S-3 | 10S (7) | 2-({4-[(1...)
Affinity DataKi:  180nM ΔG°:  -38.6kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24685(10-thiomethyl-DDACTHF, 10R-3 | 10R (8) | 2-({4-[(1...)
Affinity DataKi:  180nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24685(10-thiomethyl-DDACTHF, 10R-3 | 10R (8) | 2-({4-[(1...)
Affinity DataKi:  210nM ΔG°:  -38.2kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24686(10-thiomethyl-DDACTHF, 10S-3 | 10S (7) | 2-({4-[(1...)
Affinity DataKi:  210nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22587(7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)ox...)
Affinity DataKi:  230nM ΔG°:  -37.5kJ/molepH: 7.4 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24689(10-methoxy-DDACTHF, 10R-8 | 2-({4-[(1R)-4-(2,4-dia...)
Affinity DataKi:  850nM ΔG°:  -34.8kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24687(10-hydroxy-DDACTHF, 10R-7 | 2-({4-[(1R)-4-(2,4-dia...)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.1kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24691(2-[(4-{2-[3-(2,4-diamino-6-oxo-1,6-dihydropyrimidi...)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.1kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24690(10-methoxy-DDACTHF, 10S-8 | 2-({4-[(1S)-4-(2,4-dia...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.9kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24688(10-hydroxy-DDACTHF, 10S-7 | 2-({4-[(1S)-4-(2,4-dia...)
Affinity DataKi:  1.40E+3nM ΔG°:  -33.5kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24692(2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5...)
Affinity DataKi:  1.70E+3nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24692(2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5...)
Affinity DataKi:  1.70E+3nM ΔG°:  -33.0kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22588(Nucleotide, 3 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...)
Affinity DataKi:  4.80E+3nM ΔG°:  -30.5kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50186740(CHEMBL381706 | N-((1H-tetrazol-5-yl)methyl)-4-(6-(...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of human recombinant GAR TfaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22578(2-[(E)-2-[5-hydroxy-3-methyl-1-(2-methyl-4-sulfoph...)
Affinity DataKi:  7.10E+3nM ΔG°:  -29.1kJ/mole IC50:  1.16E+4nMpH: 7.5 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay. The assay buffer was flushed with nitrogen to minimize oxidization of cofactor 10-f-THF. The...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24692(2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5...)
Affinity DataKi:  2.00E+4nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24692(2-({4-[4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5...)
Affinity DataKi:  2.00E+4nM ΔG°:  -26.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24691(2-[(4-{2-[3-(2,4-diamino-6-oxo-1,6-dihydropyrimidi...)
Affinity DataKi:  2.00E+4nM ΔG°:  -26.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50186741(2-(4-(6-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-...)
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition of human recombinant GAR TfaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50186739((2S)-2-(4-(6-(2,4-diamino-6-oxo-1,6-dihydropyrimid...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human recombinant AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50186740(CHEMBL381706 | N-((1H-tetrazol-5-yl)methyl)-4-(6-(...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant AICAR TfaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoribosylglycinamide formyltransferase(Escherichia coli (strain K12))
The Scripps Research Institute

LigandPNGBDBM22588(Nucleotide, 3 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22585(1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22587(7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)ox...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22585(1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.5 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22587(7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)ox...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.5 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22588(Nucleotide, 3 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.5 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24685(10-thiomethyl-DDACTHF, 10R-3 | 10R (8) | 2-({4-[(1...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24686(10-thiomethyl-DDACTHF, 10S-3 | 10S (7) | 2-({4-[(1...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24687(10-hydroxy-DDACTHF, 10R-7 | 2-({4-[(1R)-4-(2,4-dia...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24688(10-hydroxy-DDACTHF, 10S-7 | 2-({4-[(1S)-4-(2,4-dia...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24689(10-methoxy-DDACTHF, 10R-8 | 2-({4-[(1R)-4-(2,4-dia...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24690(10-methoxy-DDACTHF, 10S-8 | 2-({4-[(1S)-4-(2,4-dia...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24693(10-CF3CO-DDACTHF (5) | 10-CF3CO-DDACTHF, 2 | 2-({4...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM22590((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.4 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24686(10-thiomethyl-DDACTHF, 10S-3 | 10S (7) | 2-({4-[(1...)
Affinity DataKi: >1.00E+5nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24685(10-thiomethyl-DDACTHF, 10R-3 | 10R (8) | 2-({4-[(1...)
Affinity DataKi: >1.00E+5nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM24693(10-CF3CO-DDACTHF (5) | 10-CF3CO-DDACTHF, 2 | 2-({4...)
Affinity DataKi: >1.00E+5nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM119131(Lometrexol (3))
Affinity DataKi: >1.00E+5nMAssay Description:Enzyme activity assays of recombinant hGAR Tfase and recombinant hAICAR Tfase were performed as previously described. Kinetics of the enzyme reaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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