Target

Ligand

Substrate

Meas. Tech.

TF-FVIIa Enzyme Inhibition Assay

Temperature

298.15±n/a K

Citation

 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores. Bioorg Med Chem 17:3934-58 (2009) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,   Solution Info,  Assay Method

Name:

Serine protease 1

Synonyms:

Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I

Type:

Enzyme

Mol. Mass.:

25790.52

Organism:

Bos taurus (bovine)

Description:

P00760

Residue:

246

Sequence:

MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN

Blast this sequence in BindingDB or PDB

  
Blast E-value cutoff:

Name:

BDBM31467

Synonyms:

substituted biphenyl derivative, 36g

Type:

Small organic molecule

Emp. Form.:

C29H30N4O4

Mol. Mass.:

498.5729

SMILES:

CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C(C)=C

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

L-BAPNA

Synonyms:

BANI | L-BAPA | Nalpha-Benzoyl-L-arginine 4-nitroanilide hydrochloride

Type:

chromogenic substrate

Mol. Mass.:

358.43

Organism:

n/a

Description:

n/a

Residue:

3

Sequence:

NA