Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM36328
Substrate
BDBM36388
Meas. Tech.
Assay name: Protease Inhibition Assay
pH
5.5±0
Temperature
310.15±0 K
IC50
15±n/a nM
Citation
 Kato, D; Boatright, KM; Berger, AB; Nazif, T; Blum, G; Ryan, C; Chehade, KA; Salvesen, GS; Bogyo, M Activity-based probes that target diverse cysteine protease families. Nat Chem Biol 1:33-8 (2005) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
CATB_RAT | Ctsb
Type:
Protein
Mol. Mass.:
37463.53
Organism:
Rattus norvegicus
Description:
P00787
Residue:
339
Sequence:
MWWSLIPLSCLLALTSAHDKPSSHPLSDDMINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPNLPERVGFSEDINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWGIENGVPYWLVANSWNVDWGDNGFFKILRGENHCGIESEIVAGIPRTQQYWGRF
  
Inhibitor
Name:
BDBM36328
Synonyms:
Z-FR-AMOK 9b
Type:
Small organic molecule
Emp. Form.:
C33H39N5O6
Mol. Mass.:
601.6927
SMILES:
[#6]-c1cccc(-[#6])c1-[#6](=O)-[#8]-[#6]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#8]-[#6]-c1ccccc1
Structure:
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Substrate
Name:
BDBM36388
Synonyms:
BDBM36404 | CID54445 | Octahydro-indolizine-1,6,7,8-tetraol, 13
Type:
Small organic molecule
Emp. Form.:
C8H15NO4
Mol. Mass.:
189.209
SMILES:
O[C@H]1CCN2C[C@H](O)[C@@H](O)[C@H](O)[C@@H]12
Structure:
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