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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM22774
Substrate
n/a
Meas. Tech.
ChEMBL_1668048 (CHEMBL4017936)
IC50
13900±n/a nM
Citation
 Ishiba, H; Noguchi, T; Shu, K; Ohno, H; Honda, K; Kondoh, Y; Osada, H; Fujii, N; Oishi, S Investigation of the inhibitory mechanism of apomorphine against MDM2-p53 interaction. Bioorg Med Chem Lett 27:2571-2574 (2017) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM22774
Synonyms:
1,4-Benzoquinone | Benzil-related compound, 53 | CHEMBL8320 | benzoquinone | cid_4650 | cyclohexa-2,5-diene-1,4-dione
Type:
Small organic molecule
Emp. Form.:
C6H4O2
Mol. Mass.:
108.0948
SMILES:
O=C1C=CC(=O)C=C1 |c:2,6|
Structure:
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