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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50246727
Substrate
n/a
Meas. Tech.
ChEMBL_1676735 (CHEMBL4026878)
Ki
2000±n/a nM
Citation
 Fish, I; Stößel, A; Eitel, K; Valant, C; Albold, S; Huebner, H; Möller, D; Clark, MJ; Sunahara, RK; Christopoulos, A; Shoichet, BK; Gmeiner, P Structure-Based Design and Discovery of New M J Med Chem 60:9239-9250 (2017) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50246727
Synonyms:
CHEMBL4075227
Type:
Small organic molecule
Emp. Form.:
C13H19NO
Mol. Mass.:
205.2961
SMILES:
COc1cccc2CCC(Cc12)N(C)C
Structure:
Search PDB for entries with ligand similarity: