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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Ligand
BDBM50272569
Substrate
n/a
Meas. Tech.
ChEMBL_1712423 (CHEMBL4122472)
IC50
41±n/a nM
Citation
 Humphrey, JM; Movsesian, M; Am Ende, CW; Becker, SL; Chappie, TA; Jenkinson, S; Liras, JL; Liras, S; Orozco, C; Pandit, J; Vajdos, FF; Vandeput, F; Yang, E; Menniti, FS Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1. J Med Chem 61:4635-4640 (2018) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Type:
Enzyme
Mol. Mass.:
51842.76
Organism:
Homo sapiens (Human)
Description:
Q9NP56
Residue:
450
Sequence:
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
  
Inhibitor
Name:
BDBM50272569
Synonyms:
CHEMBL4128481
Type:
Small organic molecule
Emp. Form.:
C17H21N5O2
Mol. Mass.:
327.3809
SMILES:
COc1ccc2c(N[C@@H](C)Cc3cc(C)[nH]n3)ncnc2c1OC |r|
Structure:
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