Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase 17A
Ligand
BDBM50274640
Substrate
n/a
Meas. Tech.
ChEMBL_1714184 (CHEMBL4124233)
IC50
10.0±n/a nM
Citation
 Pemberton, N; Mogemark, M; Arlbrandt, S; Bold, P; Cox, RJ; Gardelli, C; Holden, NS; Karabelas, K; Karlsson, J; Lever, S; Li, X; Lindmark, H; Norberg, M; Perry, MWD; Petersen, J; Rodrigo Blomqvist, S; Thomas, M; Tyrchan, C; Westin Eriksson, A; Zlatoidsky, P; ึster, L Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-? Inhibitors. J Med Chem 61:5435-5441 (2018) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 17A
Synonyms:
DRAK1 | ST17A_HUMAN | STK17A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46544.04
Organism:
Homo sapiens (Human)
Description:
gi_109255245
Residue:
414
Sequence:
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
  
Inhibitor
Name:
BDBM50274640
Synonyms:
CHEMBL4126445
Type:
Small organic molecule
Emp. Form.:
C20H23N3O2S
Mol. Mass.:
369.481
SMILES:
C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1sc(NC(C)=O)nc1C |r|
Structure:
Search PDB for entries with ligand similarity: