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Target
Protein Mdm4
Ligand
BDBM50287725
Substrate
n/a
Meas. Tech.
ChEMBL_1729769 (CHEMBL4145047)
IC50
82±n/a nM
Citation
 Merlino, F; Daniele, S; La Pietra, V; Di Maro, S; Di Leva, FS; Brancaccio, D; Tomassi, S; Giuntini, S; Cerofolini, L; Fragai, M; Luchinat, C; Reichart, F; Cavallini, C; Costa, B; Piccarducci, R; Taliani, S; Da Settimo, F; Martini, C; Kessler, H; Novellino, E; Marinelli, L Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme. J Med Chem 61:4791-4809 (2018) [PubMed]  Article 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50287725
Synonyms:
CHEMBL4162220
Type:
Small organic molecule
Emp. Form.:
C24H24N6O5
Mol. Mass.:
476.4846
SMILES:
NC(=N)Nc1cccc(c1)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)Nc1cccc2ccccc12 |r|
Structure:
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