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Target
Complement factor D
Ligand
BDBM50332017
Substrate
n/a
Meas. Tech.
ChEMBL_1734432 (CHEMBL4149968)
Kd
>2000000±n/a nM
Citation
 Vulpetti, A; Ostermann, N; Randl, S; Yoon, T; Mac Sweeney, A; Cumin, F; Lorthiois, E; Rüdisser, S; Erbel, P; Maibaum, J Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett 9:490-495 (2018) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM50332017
Synonyms:
CHEMBL4165382
Type:
Small organic molecule
Emp. Form.:
C20H24N4O2
Mol. Mass.:
352.4302
SMILES:
NC(=O)c1cc2c(NC(=O)C34CC5CC(CC(N)(C5)C3)C4)cccc2[nH]1 |TLB:20:10:18:13.14.15,8:10:18:13.14.15,17:16:11:13.20.14,THB:20:14:11.10.19:18,15:14:11:19.16.18,15:16:11:13.20.14|
Structure:
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