Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM50330412
Substrate
n/a
Meas. Tech.
ChEMBL_1734433 (CHEMBL4149969)
Kd
80000±n/a nM
Citation
 Vulpetti, A; Ostermann, N; Randl, S; Yoon, T; Mac Sweeney, A; Cumin, F; Lorthiois, E; Rüdisser, S; Erbel, P; Maibaum, J Discovery and Design of First Benzylamine-Based Ligands Binding to an Unlocked Conformation of the Complement Factor D. ACS Med Chem Lett 9:490-495 (2018) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM50330412
Synonyms:
CHEMBL4161222
Type:
Small organic molecule
Emp. Form.:
C24H24N2O
Mol. Mass.:
356.4602
SMILES:
NCc1cccc(c1)-c1cccc(c1)C(=O)N[C@@H]1CCCc2ccccc12 |r|
Structure:
Search PDB for entries with ligand similarity: