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Target
Trans-sialidase
Ligand
BDBM50467188
Substrate
n/a
Meas. Tech.
ChEMBL_1795339 (CHEMBL4267456)
Ki
140000±n/a nM
Citation
 Chen, Z; Marcé, P; Resende, R; Alzari, PM; Frasch, AC; van den Elsen, JMH; Crennell, SJ; Watts, AG The synthesis and kinetic evaluation of aryl ?-aminophosphonates as novel inhibitors of T. cruzi trans-sialidase. Eur J Med Chem 158:25-33 (2018) [PubMed]  Article 
Target
Name:
Trans-sialidase
Synonyms:
TCTS-154 | Trans-sialidase
Type:
PROTEIN
Mol. Mass.:
110095.63
Organism:
Trypanosoma cruzi
Description:
ChEMBL_117507
Residue:
1060
Sequence:
MGKTVVGASRMFWLMFFVPLLLALCPSEPAHALAPGSSRVELFKRQSSKVPFEKGGKVTERVVHSFRLPALVNVDGVMVAIADARYETSNDNSLIDTVAKYSVDDGETWETQIAIKNSRASSVSRVVDPTVIVKGNKLYVLVGSYNSSRSYWTSHGDARDWDILLAVGEVTKSTAGGKITASIKWGSPVSLKEFFPAEMEGMHTNQFLGGAGVAIVASNGNLVYPVQVTNKKKQVFSKIFYSEDEGKTWKFGEGRSDFGCSEPVALEWEGKLIINTRVDYRRRLVYESSDMGNSWVEAVGTLSRVWGPSPKSNQPGSQSSFTAVTIEGMRVMLFTHPLNFKGRWLRDRLNLWLTDNQRIYNVGQVSIGDENSAYSSVLYKDDKLYCLHEINSNEVYSLVFARLVGELRIIKSVLQSWKNWDSHLSSICTPADPAASSSERGCGPAVTTVGLVGFLSHSATKTEWEDAYRCVNASTANAERVPNGLKFAGVGGGALWPVSQQGQNQRYHFANHAFTLVASVTIHEVPSVASPLLGASLDSSGGKKLLGLSYDEKHQWQPIYGSTPVTPTGSWEMGKRYHVVLTMANKIGSVYIDGEPLEGSGQTVVPDGRTPDISHFYVGGYGRSDMPTISHVTVNNVLLYNRQLNAEEIRTLFLSQDLIGTEAHMGSSSGSSAHSTPSTPADNGAHSTPSTPADSSAHSTPSTPADSSAHSTPSAPGDNGAHSTPSTPGDSSAHSTPSTPADNGAHSTPSAPADSNAHSTPSTPADNGAHSTPSTPADNGAHSTPSTPGDNGAHSTPSTPGDSSAHSTPSTPADNGAHSTPSAPADSNAHSTPSTPGDNGAHSTPSAPADSNAHSTPSTPADSSAHSTPSAPGDNGAHSTPSAPADSSAHSTPSAPGDNGAHSTPSAPADNGAHSTPSAPGDSNAHSTPSTPADSSAHSTPSTPADSSAHSTPSAPGDNGAHSTPSAPADSSAHSTPSIPGDSSAHSTPSAPADSSAHSTPSAPGDNGAHSTPSTPADNGANGTVLILHDGAAFSAFSGGGLLLCAGALLLHVFVMAVFF
  
Inhibitor
Name:
BDBM50467188
Synonyms:
CHEMBL4295254
Type:
Small organic molecule
Emp. Form.:
C17H15N2O5P
Mol. Mass.:
358.2852
SMILES:
OP(O)(=O)C(Nc1cccc2ccccc12)c1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: