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Target
Delta-type opioid receptor
Ligand
BDBM50474323
Substrate
n/a
Meas. Tech.
ChEMBL_145630 (CHEMBL857860)
Ki
2951±n/a nM
Citation
 Kolczewski, S; Adam, G; Cesura, AM; Jenck, F; Hennig, M; Oberhauser, T; Poli, SM; Rössler, F; Röver, S; Wichmann, J; Dautzenberg, FM Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists. J Med Chem 46:255-64 (2003) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50474323
Synonyms:
CHEMBL2112341
Type:
Small organic molecule
Emp. Form.:
C31H50N4O
Mol. Mass.:
494.7549
SMILES:
[H][C@]12CN(CCN3CCOCC3)C[C@@]1([H])C1(CCN(CC1)[C@@H]1CC[C@@H](CC1)C(C)C)N(C2)c1ccccc1 |wU:21.23,24.30,1.0,13.15,(8.25,-5.32,;7.14,-4.25,;8.39,-3.34,;7.92,-1.87,;8.84,-.63,;10.37,-.79,;11.27,.44,;10.67,1.86,;11.56,3.09,;13.1,2.93,;13.73,1.53,;12.81,.28,;6.38,-1.87,;5.89,-3.34,;4.87,-2.19,;4.64,-4.24,;3.73,-2.99,;2.21,-3.15,;1.58,-4.55,;2.49,-5.81,;4.01,-5.64,;.05,-4.71,;-.85,-3.47,;-2.39,-3.63,;-3.02,-5.04,;-2.11,-6.29,;-.57,-6.13,;-4.56,-5.19,;-5.45,-3.94,;-5.19,-6.6,;5.13,-5.71,;6.67,-5.71,;4.29,-6.99,;2.75,-6.89,;1.89,-8.16,;2.59,-9.56,;4.12,-9.65,;4.97,-8.37,)|
Structure:
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