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Target
Nociceptin receptor
Ligand
BDBM50474322
Substrate
n/a
Meas. Tech.
ChEMBL_148273 (CHEMBL750190)
Ki
1.20±n/a nM
Citation
 Kolczewski, S; Adam, G; Cesura, AM; Jenck, F; Hennig, M; Oberhauser, T; Poli, SM; Rössler, F; Röver, S; Wichmann, J; Dautzenberg, FM Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists. J Med Chem 46:255-64 (2003) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50474322
Synonyms:
CHEMBL2112345
Type:
Small organic molecule
Emp. Form.:
C26H41N3
Mol. Mass.:
395.6238
SMILES:
[H][C@]12CN(C)C[C@@]1([H])C1(CCN(CC1)[C@@H]1CC[C@@H](CC1)C(C)C)N(C2)c1ccccc1 |wU:14.15,17.22,6.7,1.0,(17.01,-3.4,;15.89,-2.33,;17.15,-1.42,;16.68,.04,;17.59,1.28,;15.15,.05,;14.66,-1.42,;13.63,-.28,;13.4,-2.33,;12.77,-3.73,;11.26,-3.89,;10.35,-2.64,;10.98,-1.23,;12.49,-1.07,;8.81,-2.8,;7.9,-1.56,;6.37,-1.72,;5.74,-3.12,;6.65,-4.38,;8.18,-4.22,;4.2,-3.28,;3.57,-4.69,;3.32,-2.03,;13.89,-3.8,;15.43,-3.8,;13.05,-5.08,;13.73,-6.45,;12.89,-7.74,;11.35,-7.65,;10.65,-6.27,;11.51,-4.98,)|
Structure:
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