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Target
Nociceptin receptor
Ligand
BDBM50474325
Substrate
n/a
Meas. Tech.
ChEMBL_148273 (CHEMBL750190)
Ki
2.1±n/a nM
Citation
 Kolczewski, S; Adam, G; Cesura, AM; Jenck, F; Hennig, M; Oberhauser, T; Poli, SM; Rössler, F; Röver, S; Wichmann, J; Dautzenberg, FM Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists. J Med Chem 46:255-64 (2003) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50474325
Synonyms:
CHEMBL2112343
Type:
Small organic molecule
Emp. Form.:
C32H45N3
Mol. Mass.:
471.7198
SMILES:
[H][C@]12CN(Cc3ccccc3)C[C@@]1([H])C1(CCN(CC1)[C@@H]1CC[C@@H](CC1)C(C)C)N(C2)c1ccccc1 |wU:20.22,23.29,12.14,1.0,(8.65,-5.09,;7.53,-4.02,;8.79,-3.11,;8.32,-1.64,;9.23,-.4,;10.77,-.56,;11.66,.68,;13.19,.51,;13.82,-.89,;12.91,-2.13,;11.38,-1.96,;6.79,-1.64,;6.3,-3.11,;5.27,-1.96,;5.06,-4.01,;4.43,-5.41,;2.9,-5.58,;1.99,-4.32,;2.62,-2.92,;4.15,-2.76,;.45,-4.48,;-.46,-3.24,;-1.98,-3.4,;-2.61,-4.81,;-1.7,-6.06,;-.18,-5.89,;-4.15,-4.96,;-5.05,-3.71,;-4.79,-6.37,;5.53,-5.47,;7.07,-5.47,;4.69,-6.76,;3.15,-6.66,;2.31,-7.93,;2.99,-9.33,;4.53,-9.42,;5.38,-8.14,)|
Structure:
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