Target
Integrase
Ligand
BDBM50021581
Substrate
n/a
Meas. Tech.
ChEMBL_666886 (CHEMBL1262283)
IC50
13±n/a nM
Citation
 Garvey, EPJohns, BAGartland, MJFoster, SAMiller, WHFerris, RGHazen, RJUnderwood, MRBoros, EEThompson, JBWeatherhead, JGKoble, CSAllen, SHSchaller, LTSherrill, RGYoshinaga, TKobayashi, MWakasa-Morimoto, CMiki, SNakahara, KNoshi, TSato, AFujiwara, T The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral. Antimicrob Agents Chemother 52:901-8 (2008) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50021581
Synonyms:
CHEMBL414850 | L-870810
Type:
Small organic molecule
Emp. Form.:
C20H19FN4O4S
Mol. Mass.:
430.453
SMILES:
O\C(=N/Cc1ccc(F)cc1)c1nc(N2CCCCS2(=O)=O)c2cccnc2c1O
Structure:
Search PDB for entries with ligand similarity: