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Target
Integrase
Ligand
BDBM50478002
Substrate
n/a
Meas. Tech.
ChEMBL_689634 (CHEMBL1635106)
IC50
40±n/a nM
Citation
 Jones, GS; Yu, F; Zeynalzadegan, A; Hesselgesser, J; Chen, X; Chen, J; Jin, H; Kim, CU; Wright, M; Geleziunas, R; Tsiang, M Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother 53:1194-203 (2009) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50478002
Synonyms:
CHEMBL408699
Type:
Small organic molecule
Emp. Form.:
C23H23ClFNO5
Mol. Mass.:
447.884
SMILES:
COc1cc2n(cc(C(O)=O)c(=O)c2cc1Cc1cccc(Cl)c1F)[C@@H](CO)C(C)C
Structure:
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