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maximum 50k data
Found 54 with Last Name = 'tsiang' and Initial = 'm'
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187196(2'-[(4-fluorophenyl)methyl]-4'-hydroxy-9'-methoxy-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187771(7-(4-fluorobenzyl)-3-fluoro-9-hydroxy-5-methoxy-6,...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of strand transfer activity in HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM27749(3-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,...)
Affinity DataIC50:  14nMpH: 7.3 T: 2°CAssay Description:In the strand-transfer assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow proce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50:  19nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM23400((2Z)-4-(3-benzylphenyl)-2-hydroxy-4-oxobut-2-enoic...)
Affinity DataIC50:  26nMpH: 7.3 T: 2°CAssay Description:In the 3-end joining assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow process...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50483196(CHEMBL513189 | GS-9160)
Affinity DataIC50:  28nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187770(7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of strand transfer activity in HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  34nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187194(7-(4-fluorobenzyl)-6,9-dihydroxy-5-methoxy-6,7-dih...)
Affinity DataIC50:  36nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187761(7-(4-fluorobenzyl)-9-hydroxy-5-(morpholine-4-carbo...)
Affinity DataIC50:  36nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM23399(4-{1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl}-2,4-...)
Affinity DataIC50:  37nMpH: 7.3 T: 2°CAssay Description:In the 3-end joining assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow process...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50478002(CHEMBL408699)
Affinity DataIC50:  40nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM23401(6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2R)-1-hydr...)
Affinity DataIC50:  42nMpH: 7.3 T: 2°CAssay Description:In the 3-end joining assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow process...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM23402(5-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(4-fluoropheny...)
Affinity DataIC50:  44nMpH: 7.3 T: 2°CAssay Description:In the 3-end joining assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow process...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50021581(CHEMBL414850 | L-870810)
Affinity DataIC50:  44nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM23398((2Z)-1-{5-[(4-fluorophenyl)methyl]furan-2-yl}-3-hy...)
Affinity DataIC50:  46nMpH: 7.3 T: 2°CAssay Description:In the 3-end joining assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow process...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM23403(7-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,...)
Affinity DataIC50:  50nMAssay Description:Inhibition of strand transfer activity in HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM23403(7-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,...)
Affinity DataIC50:  50nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM23402(5-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(4-fluoropheny...)
Affinity DataIC50:  50nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187198(7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-(3-oxo-3-...)
Affinity DataIC50:  59nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM23403(7-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,...)
Affinity DataIC50:  60nMpH: 7.3 T: 2°CAssay Description:In the 3-end joining assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow process...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM23403(7-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-6H,...)
Affinity DataIC50:  60nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187191(7-(4-fluorobenzyl)-9-hydroxy-5,6-dimethoxy-6,7-dih...)
Affinity DataIC50:  64nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187760(7-(4-fluorobenzyl)-9-hydroxy-6,7-dihydropyrrolo[3,...)
Affinity DataIC50:  70nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187764(7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6H-pyrrolo[...)
Affinity DataIC50:  80nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187186(7-(4-fluorobenzyl)-5,9-dihydroxy-7H-pyrrolo[3,4-g]...)
Affinity DataIC50:  80nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM27751(N-{3-[(4-fluorophenyl)methyl]-9-hydroxy-7-methyl-8...)
Affinity DataIC50:  80nMpH: 7.3 T: 2°CAssay Description:In the strand-transfer assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow proce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187190(7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-methyl-6,...)
Affinity DataIC50:  88nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187773(7-(4-fluorobenzyl)-9-hydroxy-3,5-dimethoxy-6,7-dih...)
Affinity DataIC50:  93nMAssay Description:Inhibition of strand transfer activity in HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM27748(3-[(4-fluorophenyl)methyl]-9-hydroxy-5-methoxy-7-m...)
Affinity DataIC50:  100nMpH: 7.3 T: 2°CAssay Description:In the strand-transfer assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow proce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187185(7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6-methylene...)
Affinity DataIC50:  150nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187759(7-(4-fluorobenzyl)-9-hydroxy-8-oxo-N-(pyridin-2-yl...)
Affinity DataIC50:  190nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187193(7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-6,6-dimethy...)
Affinity DataIC50:  210nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187769(7-(4-fluorobenzyl)-5-hydroxy-9-methoxy-7,8-dihydro...)
Affinity DataIC50:  210nMAssay Description:Inhibition of strand transfer activity in HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187187(7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-...)
Affinity DataIC50:  255nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187187(7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-...)
Affinity DataIC50:  255nMAssay Description:Inhibition of strand transfer activity in HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM27752(N-{3-[(3-chloro-4-fluorophenyl)methyl]-9-hydroxy-7...)
Affinity DataIC50:  265nMpH: 7.3 T: 2°CAssay Description:In the strand-transfer assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow proce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187197(3-(7-(4-fluorobenzyl)-9-hydroxy-5-methoxy-8-oxo-7,...)
Affinity DataIC50:  295nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187188(CHEMBL209641 | methyl 3-(7-(4-fluorobenzyl)-9-hydr...)
Affinity DataIC50:  310nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187765(5-(2,6-difluorophenyl)-7-(4-fluorobenzyl)-9-hydrox...)
Affinity DataIC50:  335nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187767(CHEMBL378395 | ethyl 2-(7-(4-fluorobenzyl)-9-hydro...)
Affinity DataIC50:  350nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187189(2'-[(4-fluorophenyl)methyl]-4'-hydroxy-3'-oxo-2',3...)
Affinity DataIC50:  357nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187192(7-(4-fluorobenzyl)-9-hydroxy-6-methylene-8-oxo-7,8...)
Affinity DataIC50:  420nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gilead Sciences

LigandPNGBDBM27750(3,7-bis[(4-fluorophenyl)methyl]-9-hydroxy-5-methox...)
Affinity DataIC50:  600nMpH: 7.3 T: 2°CAssay Description:In the strand-transfer assay, the biotinylated donor DNA was bound to streptavidin-coated plates, and integrase was added to each well to allow proce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187763(7-(4-fluorobenzyl)-9-hydroxy-8-oxo-7,8-dihydro-6H-...)
Affinity DataIC50:  760nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187195(7-(4-fluorobenzyl)-9-hydroxy-6-methyl-8-oxo-7,8-di...)
Affinity DataIC50:  815nMAssay Description:Inhibition of HIV1 integrase strand transfer activity in MT4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187772(7-(4-fluoro-benzyl)-5-hydroxy-9-methoxy-1,2,3,4,7,...)
Affinity DataIC50:  850nMAssay Description:Inhibition of strand transfer activity in HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187758(5-(4-ethoxyphenyl)-7-(4-fluorobenzyl)-6H-pyrrolo[3...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187768(CHEMBL209591 | N-(4-fluorobenzyl)-8-hydroxyquinoli...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50187762(CHEMBL211275 | ethyl 3-(7-(4-fluorobenzyl)-9-hydro...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of strand transfer activity of HIV integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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