Reaction Details Report a problem with these data
Target
Reverse transcriptase
Ligand
BDBM50478158
Substrate
n/a
Meas. Tech.
ChEMBL_827266 (CHEMBL2050665)
Kd
16500±n/a nM
Citation
 Kim, J; Wang, L; Li, Y; Becnel, KD; Frey, KM; Garforth, SJ; Prasad, VR; Schinazi, RF; Liotta, DC; Anderson, KS Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett 22:4064-7 (2012) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50478158
Synonyms:
Tenofovir diphospahte | tenofovir diphosphate
Type:
Small organic molecule
Emp. Form.:
C9H16N5O10P3
Mol. Mass.:
447.1721
SMILES:
C[C@@H](Cn1cnc2c(N)ncnc12)OCP(O)(=O)OP(O)(=O)OP(O)(O)=O
Structure:
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