Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50029099
Substrate
n/a
Meas. Tech.
ChEMBL_152588 (CHEMBL759766)
Ki
59±n/a nM
Citation
 Bondinell, WE; Chapin, FW; Girard, GR; Kaiser, C; Krog, AJ; Pavloff, AM; Schwartz, MS; Silvestri, JS; Vaidya, PD; Lam, BL; Wellman, GR; Pendleton, RG Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 1. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines. J Med Chem 23:506-11 (1980) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:
Enzyme
Mol. Mass.:
30852.66
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
  
Inhibitor
Name:
BDBM50029099
Synonyms:
5,7,8-Trichloro-1,2,3,4-tetrahydro-isoquinoline | CHEMBL149535
Type:
Small organic molecule
Emp. Form.:
C9H8Cl3N
Mol. Mass.:
236.526
SMILES:
Clc1cc(Cl)c2CCNCc2c1Cl
Structure:
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