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Found 48 with Last Name = 'pendleton' and Initial = 'rg'
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3nMAssay Description:Binding affinity for phenylethanolamine N-methyl-transferase was determined.More data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3nMAssay Description:Dissociation constant(Ki) of compound was determined to measure PNMT-inhibitory potencyMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Bos taurus (bovine))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50018237(6,7,8,9-Tetrahydro-3-thia-1,2,8-triaza-cyclopenta[...)
Affinity DataKi:  8nMAssay Description:Binding affinity for phenylethanolamine N-methyl-transferase was determined.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029108(6,7,8-Trichloro-1,2,3,4-tetrahydro-isoquinoline | ...)
Affinity DataKi:  20nMAssay Description:In vitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029102(7-Chloro-1,2,3,4-tetrahydro-isoquinoline | CHEMBL1...)
Affinity DataKi:  29nMAssay Description:Dissociation constant(Ki) of compound was determined to measure PNMT-inhibitory potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029107(8-Chloro-1,2,3,4-tetrahydro-isoquinoline | CHEMBL1...)
Affinity DataKi:  30nMAssay Description:In vitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029101(5,6,7,8-Tetrachloro-1,2,3,4-tetrahydro-isoquinolin...)
Affinity DataKi:  52nMAssay Description:Dissociation constant(Ki) of compound was determined to measure Phenylethanolamine N-methyltransferase inhibitory potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029099(5,7,8-Trichloro-1,2,3,4-tetrahydro-isoquinoline | ...)
Affinity DataKi:  59nMAssay Description:Dissociation constant(Ki) of compound was determined to measure PNMT-inhibitory potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataIC50:  10nMAssay Description:Dissociation constant(Ki) of compound was determined to measure PNMT-inhibitory potencyMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028902(7,8-dichloro-2-[2-(7,8-dichloro-1,2,3,4-tetrahydro...)
Affinity DataIC50:  80nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028908(7,8-dichloro-2-[4-(7,8-dichloro-1,2,3,4-tetrahydro...)
Affinity DataIC50:  100nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029108(6,7,8-Trichloro-1,2,3,4-tetrahydro-isoquinoline | ...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029102(7-Chloro-1,2,3,4-tetrahydro-isoquinoline | CHEMBL1...)
Affinity DataIC50:  200nMAssay Description:Dissociation constant(Ki) of compound was determined to measure Phenylethanolamine N-methyltransferase inhibitory potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029107(8-Chloro-1,2,3,4-tetrahydro-isoquinoline | CHEMBL1...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029101(5,6,7,8-Tetrachloro-1,2,3,4-tetrahydro-isoquinolin...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028903(7,8-dichloro-2-[3-(7,8-dichloro-1,2,3,4-tetrahydro...)
Affinity DataIC50:  300nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029099(5,7,8-Trichloro-1,2,3,4-tetrahydro-isoquinoline | ...)
Affinity DataIC50:  300nMAssay Description:Dissociation constant(Ki) of compound was determined to measure Phenylethanolamine N-methyltransferase inhibitory potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029106(2,3-Dichloro-benzylamine | CHEMBL13165)
Affinity DataIC50:  600nMAssay Description:Invitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028910(7,8-dichloro-2-[6-(7,8-dichloro-1,2,3,4-tetrahydro...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028914(7,8-dichloro-2-[7-(7,8-dichloro-1,2,3,4-tetrahydro...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028911(7,8-dichloro-2-[8-(7,8-dichloro-1,2,3,4-tetrahydro...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028909(2-(7,8-Dichloro-3,4-dihydro-1H-isoquinolin-2-yl)-e...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028901(7,8-Dichloro-2-ethyl-1,2,3,4-tetrahydro-isoquinoli...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028913(7,8-Dichloro-2-propyl-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028912(2-Benzyl-7,8-dichloro-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM12584((3-chlorophenyl)methanamine | 1-(3-CHLOROPHENYL)ME...)
Affinity DataIC50:  9.00E+3nMAssay Description:Invitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibitory activity against human phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028906(7,8-dichloro-2-[5-(7,8-dichloro-1,2,3,4-tetrahydro...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029105(2-(3,4,-dichlorophenyl)ethylamine | 2-(3,4-Dichlor...)
Affinity DataIC50:  2.00E+4nMAssay Description:In vitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029104(2-Chloro-benzylamine | CHEMBL12712)
Affinity DataIC50:  2.00E+4nMAssay Description:Invitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028905(7,8-Dichloro-2-(6-phenyl-hexyl)-1,2,3,4-tetrahydro...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029103(2-(3-Chloro-phenyl)-1-methyl-ethylamine | CHEMBL14...)
Affinity DataIC50:  6.00E+4nMAssay Description:In vitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028904(2-(6-Bromo-hexyl)-7,8-dichloro-1,2,3,4-tetrahydro-...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50028907(6-(7,8-Dichloro-3,4-dihydro-1H-isoquinolin-2-yl)-h...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of rabbit adrenal phenylethanolamine N-methyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50029100(2-(4-Chloro-phenyl)-1-methyl-ethylamine | CHEMBL35...)
Affinity DataIC50:  3.00E+5nMAssay Description:Invitro inhibitory potency of the compound was measured against phenylethanolamine N-methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026774(7,10-Dimethoxy-1,2,3,4,4a,5,6,10b-octahydro-benzo[...)
Affinity DataEC50:  170nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM23981((2S)-1,2,3,4-Tetrahydro-naphthalen-2-ylamine | 1,2...)
Affinity DataEC50: >3.00E+4nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026775(4,7-Dimethoxy-indan-2-ylamine | CHEMBL284307)
Affinity DataEC50:  3.00E+4nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026783(5,8-Dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ylam...)
Affinity DataEC50:  120nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026782(5,8-Dimethoxy-1,2,3,4-tetrahydro-isoquinoline | CH...)
Affinity DataEC50: >3.00E+4nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026781(3,6-Dimethoxy-tricyclo[6.2.2.0*2,7*]dodeca-2,4,6-t...)
Affinity DataEC50:  3.00E+4nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026779(7,10-Dimethoxy-1,2,3,4,4a,5,6,10b-octahydro-benzo[...)
Affinity DataEC50:  200nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026780(1,4-Dimethoxy-6,7,8,9-tetrahydro-5H-benzocyclohept...)
Affinity DataEC50:  5.30E+3nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026778(2-(2,5-Dimethoxy-phenyl)-ethylamine | 2-(2,5-dimet...)
Affinity DataEC50:  1.10E+4nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026773(3,6-Dimethoxy-tricyclo[6.2.2.0*2,7*]dodeca-2,4,6-t...)
Affinity DataEC50:  3.00E+4nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026777(2-Amino-1-(2,5-dimethoxy-phenyl)-propan-1-ol | 2-A...)
Affinity DataEC50:  720nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026776(2,5-Dimethoxy-1,1a,6,6a-tetrahydro-cyclopropa[a]in...)
Affinity DataEC50:  340nMAssay Description:Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed