Reaction Details
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Mu-type opioid receptor
Ligand
BDBM50038014
Substrate
n/a
Meas. Tech.
ChEMBL_136090 (CHEMBL745613)
IC50
5±n/a nM
Citation
Meyer, JP; Collins, N; Lung, FD; Davis, P; Zalewska, T; Porreca, F; Yamamura, HI; Hruby, VJ Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11. J Med Chem 37:3910-7 (1994) [PubMed] Article More Info.:
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOR-1 | Mu opioid receptor | Mu-type opioid receptor (Mu) | OPIATE Mu | OPRM1 | OPRM_CAVPO
Type:
Enzyme Catalytic Domain
Mol. Mass.:
11165.58
Organism:
GUINEA PIG
Description:
P97266
Residue:
98
Sequence:
YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
Inhibitor
Name:
BDBM50038014
Synonyms:
CHEMBL2370622 | Tyr-Gly-Gly-Phe-Cys-Arg-Arg-Ile-Arg-Pro-D-Pen-NH2
Type:
Small organic molecule
Emp. Form.:
C63H101N21O12S2
Mol. Mass.:
1408.74
SMILES:
[H][C@@]12[#6]-[#6]-[#6]-[#7]1-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)[C@@]([H])([#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccc(-[#8])cc1)C([#6])([#6])[#16]-[#6]-[#6]-[#16]C([#6])([#6])[#6@@H](-[#7]-[#6]2=O)-[#6](-[#7])=O)[#6@@H](-[#6])-[#6]-[#6]
Structure:
