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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM37337
Substrate
n/a
Meas. Tech.
ChEMBL_1276214 (CHEMBL3089537)
EC50
>50000±n/a nM
Citation
 Guerrero, M; Poddutoori, R; Urbano, M; Peng, X; Spicer, TP; Chase, PS; Hodder, PS; Schaeffer, MT; Brown, S; Rosen, H; Roberts, E Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist. Bioorg Med Chem Lett 23:6346-9 (2013) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM37337
Synonyms:
MLS000087301 | N,N-dicyclohexyl-5-methyl-1,2-oxazole-3-carboxamide | N,N-dicyclohexyl-5-methyl-3-isoxazolecarboxamide | N,N-dicyclohexyl-5-methyl-isoxazole-3-carboxamide | N,N-dicyclohexyl-5-methylisoxazole-3-carboxamide | SMR000023524 | cid_3245758
Type:
Small organic molecule
Emp. Form.:
C17H26N2O2
Mol. Mass.:
290.4005
SMILES:
Cc1cc(no1)C(=O)N(C1CCCCC1)C1CCCCC1
Structure:
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