Reaction Details
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11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50507376
Substrate
n/a
Meas. Tech.
ChEMBL_1829814 (CHEMBL4329688)
IC50
0.500000±n/a nM
Citation
Li, J; Kennedy, LJ; Walker, SJ; Wang, H; Li, JJ; Hong, Z; O'Connor, SP; Ye, XY; Chen, S; Wu, S; Yoon, DS; Nayeem, A; Camac, DM; Ramamurthy, V; Morin, PE; Sheriff, S; Wang, M; Harper, TW; Golla, R; Seethala, R; Harrity, T; Ponticiello, RP; Morgan, NN; Taylor, JR; Zebo, R; Maxwell, B; Moulin, F; Gordon, DA; Robl, JA Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11?-Hydroxysteroid Dehydrogenase Type 1 (11?-HSD-1). ACS Med Chem Lett 9:1170-1174 (2018) [PubMed] Article More Info.:
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Inhibitor
Name:
BDBM50507376
Synonyms:
CHEMBL4453347
Type:
Small organic molecule
Emp. Form.:
C20H22ClN3O
Mol. Mass.:
355.861
SMILES:
CC(C)(CCO)c1cccn2c(nnc12)C1(CC1)c1ccc(Cl)cc1
Structure:
