Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50067530
Substrate
n/a
Meas. Tech.
ChEMBL_48811 (CHEMBL662834)
Ki
8700.0±n/a nM
Citation
 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Stürzebecher, J; Moroder, L Design of benzamidine-type inhibitors of factor Xa. J Med Chem 41:4240-50 (1998) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50067530
Synonyms:
3-(4-Carbamimidoyl-phenyl)-2-[2-(4-cyano-benzenesulfonylamino)-acetylamino]-propionic acid ethyl ester | CHEMBL135198
Type:
Small organic molecule
Emp. Form.:
C21H23N5O5S
Mol. Mass.:
457.503
SMILES:
CCOC(=O)C(Cc1ccc(cc1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C#N
Structure:
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