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Target
Plasminogen
Ligand
BDBM50514075
Substrate
n/a
Meas. Tech.
ChEMBL_1855589 (CHEMBL4356318)
IC50
8.6±n/a nM
Citation
 Steinmetzer, T; Pilgram, O; Wenzel, BM; Wiedemeyer, SJA Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding. J Med Chem 63:1445-1472 (2020) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLG | PLMN_HUMAN | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:
Enzyme
Mol. Mass.:
90579.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
  
Inhibitor
Name:
BDBM50514075
Synonyms:
CHEMBL4541084
Type:
Small organic molecule
Emp. Form.:
C33H38N8O4
Mol. Mass.:
610.706
SMILES:
CCOC(=O)c1ccc(c(C)n1)-c1ccc(C[C@H](NC(=O)[C@H]2CC[C@H](CN)CC2)C(=O)Nc2ccc(cc2)-c2nn[nH]n2)cc1 |r,wU:24.25,wD:21.21,17.17,(24.34,-30.13,;23.01,-30.9,;21.67,-30.14,;20.34,-30.91,;20.35,-32.45,;19.01,-30.15,;17.67,-30.92,;16.34,-30.15,;16.34,-28.61,;17.66,-27.84,;17.66,-26.3,;19,-28.6,;15.01,-27.84,;13.67,-28.61,;12.34,-27.84,;12.35,-26.3,;11.01,-25.53,;11.01,-23.99,;9.68,-23.22,;8.34,-23.99,;7.01,-23.22,;8.34,-25.53,;7.02,-26.3,;7.02,-27.84,;8.34,-28.61,;8.34,-30.15,;7.01,-30.92,;9.67,-27.84,;9.67,-26.3,;12.35,-23.22,;12.35,-21.68,;13.68,-23.99,;15.01,-23.22,;16.34,-23.99,;17.67,-23.22,;17.68,-21.68,;16.34,-20.91,;15.01,-21.69,;19.01,-20.9,;20.42,-21.52,;21.45,-20.38,;20.68,-19.04,;19.17,-19.37,;13.67,-25.53,;15,-26.29,)|
Structure:
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