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Target
Plasminogen
Ligand
BDBM50514076
Substrate
n/a
Meas. Tech.
ChEMBL_1855589 (CHEMBL4356318)
IC50
0.400000±n/a nM
Citation
 Steinmetzer, T; Pilgram, O; Wenzel, BM; Wiedemeyer, SJA Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding. J Med Chem 63:1445-1472 (2020) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLG | PLMN_HUMAN | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:
Enzyme
Mol. Mass.:
90579.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
  
Inhibitor
Name:
BDBM50514076
Synonyms:
CHEMBL4456691
Type:
Small organic molecule
Emp. Form.:
C35H38ClN7O3
Mol. Mass.:
640.174
SMILES:
Cc1cc2[nH]c(nc2cc1-c1ccc(C[C@H](NC(=O)[C@H]2CC[C@H](CN)CC2)C(=O)Nc2cc(Cl)c3[nH]c(=O)[nH]c3c2)cc1)C1CC1 |r,wU:22.24,wD:19.20,15.16,(35.34,-31.42,;36.67,-30.65,;38,-31.42,;39.34,-30.65,;40.81,-31.11,;41.71,-29.85,;40.79,-28.61,;39.33,-29.1,;38,-28.34,;36.67,-29.11,;35.34,-28.34,;34,-29.11,;32.67,-28.34,;32.68,-26.8,;31.34,-26.03,;31.34,-24.49,;30.01,-23.72,;28.68,-24.49,;27.34,-23.72,;28.68,-26.03,;27.35,-26.81,;27.35,-28.35,;28.68,-29.11,;28.68,-30.65,;27.34,-31.42,;30,-28.35,;30,-26.81,;32.68,-23.72,;32.68,-22.18,;34.01,-24.49,;35.34,-23.72,;35.34,-22.19,;36.67,-21.42,;36.66,-19.88,;38.01,-22.18,;39.48,-21.71,;40.38,-22.96,;41.92,-22.97,;39.47,-24.21,;38,-23.72,;36.68,-24.5,;34,-26.03,;35.33,-26.8,;43.25,-29.83,;44.59,-30.59,;44.57,-29.05,)|
Structure:
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