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Target
Plasminogen
Ligand
BDBM50514078
Substrate
n/a
Meas. Tech.
ChEMBL_1855589 (CHEMBL4356318)
IC50
2.1±n/a nM
Citation
 Steinmetzer, T; Pilgram, O; Wenzel, BM; Wiedemeyer, SJA Fibrinolysis Inhibitors: Potential Drugs for the Treatment and Prevention of Bleeding. J Med Chem 63:1445-1472 (2020) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLG | PLMN_HUMAN | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:
Enzyme
Mol. Mass.:
90579.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
  
Inhibitor
Name:
BDBM50514078
Synonyms:
CHEMBL4582882
Type:
Small organic molecule
Emp. Form.:
C35H35ClN6O6
Mol. Mass.:
671.142
SMILES:
Cc1cc2c(cc1-c1ccc(C[C@H](NC(=O)[C@H]3CC[C@H](CN)CC3)C(=O)Nc3cc(Cl)c4[nH]c(=O)[nH]c4c3)cc1)[nH]cc(C(O)=O)c2=O |r,wU:19.20,wD:16.16,12.12,(35.27,-11.33,;35.27,-12.87,;36.61,-13.63,;36.61,-15.18,;35.28,-15.94,;33.95,-15.18,;33.95,-13.64,;32.61,-12.87,;31.28,-13.64,;29.95,-12.87,;29.95,-11.33,;28.61,-10.56,;28.61,-9.02,;27.29,-8.25,;25.95,-9.02,;24.62,-8.25,;25.95,-10.56,;24.62,-11.34,;24.62,-12.88,;25.95,-13.64,;25.95,-15.18,;24.62,-15.95,;27.28,-12.88,;27.28,-11.34,;29.95,-8.25,;29.95,-6.71,;31.29,-9.02,;32.62,-8.25,;32.62,-6.72,;33.94,-5.95,;33.94,-4.41,;35.28,-6.7,;36.76,-6.23,;37.67,-7.49,;39.21,-7.49,;36.75,-8.74,;35.28,-8.25,;33.95,-9.03,;31.28,-10.56,;32.61,-11.33,;35.27,-17.48,;36.6,-18.26,;37.94,-17.49,;39.26,-18.27,;40.6,-17.51,;39.26,-19.81,;37.95,-15.95,;39.28,-15.18,)|
Structure:
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