Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM50069819
Substrate
n/a
Meas. Tech.
ChEBML_85846
Ki
59±n/a nM
Citation
 Shih, NY; Aslanian, R; Lupo, AT; Orlando, S; Piwinski, JJ; Green, MJ; Ganguly, AK; West, R; Tozzi, S; Kreutner, W; Hey, JA Trans-4-methyl-3-imidazoyl pyrrolidine as a potent, highly selective histamine H3 receptor agonist in vivo. Bioorg Med Chem Lett 8:243-8 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48753.61
Organism:
GUINEA PIG
Description:
HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35
Residue:
445
Sequence:
MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGAREAGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50069819
Synonyms:
4-((2S,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole | CHEMBL81888
Type:
Small organic molecule
Emp. Form.:
C8H13N3
Mol. Mass.:
151.2089
SMILES:
C[C@@H]1NCC[C@@H]1c1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: