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Target
Caspase-1
Ligand
BDBM50072047
Substrate
n/a
Meas. Tech.
ChEBML_46514
IC50
1.20±n/a nM
Citation
 Karanewsky, DS; Bai, X; Linton, SD; Krebs, JF; Wu, J; Pham, B; Tomaselli, KJ Conformationally constrained inhibitors of caspase-1 (interleukin-1 beta converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, apopain). Bioorg Med Chem Lett 8:2757-62 (1999) [PubMed]  Article 
Target
Name:
Caspase-1
Synonyms:
CASP1_MOUSE | Casp1 | Il1bc
Type:
PROTEIN
Mol. Mass.:
45636.44
Organism:
Mus musculus
Description:
ChEMBL_651546
Residue:
402
Sequence:
MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDHVSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNKEDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVGAQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQEGICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRDSEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
  
Inhibitor
Name:
BDBM50072047
Synonyms:
4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((S)-2-hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-2-methyl-propylcarbamoyl]-butyric acid | CHEMBL430648
Type:
Small organic molecule
Emp. Form.:
C20H30N4O11
Mol. Mass.:
502.4724
SMILES:
CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@H]1CC(=O)OC1O
Structure:
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