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Found 422 with Last Name = 'tomaselli' and Initial = 'kj'
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133876((S)-3-{(S)-3-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataKi:  7.10nMAssay Description:Binding affinity of the compound was tested against caspase-3 (Csp-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133876((S)-3-{(S)-3-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataKi:  70nMAssay Description:Binding affinity of the compound was tested against Murine caspase-1 (mCsp-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133889((S)-3-{(S)-3-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataKi:  90nMAssay Description:Binding affinity of the compound was tested against caspase-3 (Csp-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133879((S)-5-(Biphenyl-4-yloxy)-3-{(S)-3-methyl-2-[2-(nap...)
Affinity DataKi:  100nMAssay Description:Binding affinity of the compound was tested against caspase-3 (Csp-3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133879((S)-5-(Biphenyl-4-yloxy)-3-{(S)-3-methyl-2-[2-(nap...)
Affinity DataKi:  2.68E+3nMAssay Description:Binding affinity of the compound was tested against Murine caspase-1 (mCsp-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133889((S)-3-{(S)-3-Methyl-2-[2-(naphthalen-1-yloxy)-acet...)
Affinity DataKi:  3.17E+3nMAssay Description:Binding affinity of the compound was tested against Murine caspase-1 (mCsp-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072047(4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072047(4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against Caspase-1 using Ac-TyrValAlaAsp-amc as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119218(4-Benzyloxycarbonylamino-4-[1-(2-hydroxy-5-oxo-tet...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory concentration of compound required against Caspase-3 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119218(4-Benzyloxycarbonylamino-4-[1-(2-hydroxy-5-oxo-tet...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory concentration of compound required against Caspase-3 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072047(4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory concentration of compound required against Caspase-3 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119267(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119245(4-(2-Acetylamino-2-carboxy-acetylamino)-4-[1-(2-hy...)
Affinity DataIC50:  3.5nMAssay Description:Inhibitory concentration of compound required against Caspase-3 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119267(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119218(4-Benzyloxycarbonylamino-4-[1-(2-hydroxy-5-oxo-tet...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory concentration of compound required against Caspase-1 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119218(4-Benzyloxycarbonylamino-4-[1-(2-hydroxy-5-oxo-tet...)
Affinity DataIC50:  6.5nMAssay Description:Inhibitory concentration of compound required against Caspase-1 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  7nMAssay Description:Binding affinity of the compound towards human Caspase-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119262(4-Methyl-2-[2-(naphthalen-1-ylamino)-acetylamino]-...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119218(4-Benzyloxycarbonylamino-4-[1-(2-hydroxy-5-oxo-tet...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of compound required against Caspase-7 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119245(4-(2-Acetylamino-2-carboxy-acetylamino)-4-[1-(2-hy...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of compound required against Caspase-6 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119245(4-(2-Acetylamino-2-carboxy-acetylamino)-4-[1-(2-hy...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of compound required against Caspase-7 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119218(4-Benzyloxycarbonylamino-4-[1-(2-hydroxy-5-oxo-tet...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of compound required against Caspase-7 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145661((S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl...)
Affinity DataIC50:  10nMAssay Description:Binding affinity of the compound towards human Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072047(4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of compound required against Caspase-7 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072047(4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration of compound required against Caspase-6 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119264(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50:  12nMAssay Description:Inhibition of Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119262(4-Methyl-2-[2-(naphthalen-1-ylamino)-acetylamino]-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  13nMAssay Description:Binding affinity of the compound towards human Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119258(CHEMBL323322 | N-(2-Hydroxy-5-oxo-tetrahydro-furan...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Caspase-1 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119264(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119261(4-Methyl-2-[2-(naphthalen-1-ylamino)-propionylamin...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072046((S)-3-Acetylamino-N-[(3R,6S,9aR)-3-((S)-2-hydroxy-...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against human Caspase-3 using Ac-AspGluValAsp as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119264(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50:  21nMAssay Description:Inhibition of Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145661((S)-3-{(S)-4-Methyl-2-[(naphthalen-1-ylaminooxalyl...)
Affinity DataIC50:  27nMAssay Description:Binding affinity of the compound towards mouse Caspase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119218(4-Benzyloxycarbonylamino-4-[1-(2-hydroxy-5-oxo-tet...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration of compound required against Caspase-8 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119218(4-Benzyloxycarbonylamino-4-[1-(2-hydroxy-5-oxo-tet...)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration of compound required against Caspase-8 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119267(4-[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamo...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  33nMAssay Description:Binding affinity of the compound towards mouse Caspase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119262(4-Methyl-2-[2-(naphthalen-1-ylamino)-acetylamino]-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Caspase-1 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072044(CHEMBL419508 | [(4S,7S,10aS)-4-((S)-2-Hydroxy-5-ox...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against Caspase-1 using Ac-TyrValAlaAsp-amc as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119262(4-Methyl-2-[2-(naphthalen-1-ylamino)-acetylamino]-...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-6(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145622((S)-3-{(S)-4-Methyl-2-[2-(naphthalen-1-ylamino)-ac...)
Affinity DataIC50:  37nMAssay Description:Binding affinity of the compound towards human Caspase-6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119233(CHEMBL101835 | {1-[1-(2-Hydroxy-5-oxo-tetrahydro-f...)
Affinity DataIC50:  43nMAssay Description:Inhibitory concentration of compound required against Caspase-1 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119266(1-{[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbam...)
Affinity DataIC50:  48nMAssay Description:Inhibition of Caspase-8 enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119245(4-(2-Acetylamino-2-carboxy-acetylamino)-4-[1-(2-hy...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration of compound required against Caspase-1 compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072047(4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((...)
Affinity DataIC50:  50nMAssay Description:Inhibitory concentration of compound required against Caspase-1 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119266(1-{[1-(2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbam...)
Affinity DataIC50:  54nMAssay Description:Inhibition of Caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50119238(4-Methyl-2-[3-(naphthalen-1-yloxy)-propionylamino]...)
Affinity DataIC50:  59nMAssay Description:Inhibitory concentration against caspase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Mus musculus)
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072042(CHEMBL328015 | {(S)-1-[(S)-1-((S)-2-Hydroxy-5-oxo-...)
Affinity DataIC50:  64nMAssay Description:Inhibitory activity against Caspase-1 using Ac-TyrValAlaAsp-amc as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Idun Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072047(4-(2-Acetylamino-3-carboxy-propionylamino)-4-[1-((...)
Affinity DataIC50:  80nMAssay Description:Inhibitory concentration of compound required against Caspase-8 enzyme compared to acylated dipeptidesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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