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Target
Caspase-1
Ligand
BDBM50072048
Substrate
n/a
Meas. Tech.
ChEBML_46514
IC50
4800±n/a nM
Citation
 Karanewsky, DS; Bai, X; Linton, SD; Krebs, JF; Wu, J; Pham, B; Tomaselli, KJ Conformationally constrained inhibitors of caspase-1 (interleukin-1 beta converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, apopain). Bioorg Med Chem Lett 8:2757-62 (1999) [PubMed]  Article 
Target
Name:
Caspase-1
Synonyms:
CASP1_MOUSE | Casp1 | Il1bc
Type:
PROTEIN
Mol. Mass.:
45636.44
Organism:
Mus musculus
Description:
ChEMBL_651546
Residue:
402
Sequence:
MADKILRAKRKQFINSVSIGTINGLLDELLEKRVLNQEEMDKIKLANITAMDKARDLCDHVSKKGPQASQIFITYICNEDCYLAGILELQSAPSAETFVATEDSKGGHPSSSETKEEQNKEDGTFPGLTGTLKFCPLEKAQKLWKENPSEIYPIMNTTTRTRLALIICNTEFQHLSPRVGAQVDLREMKLLLEDLGYTVKVKENLTALEMVKEVKEFAACPEHKTSDSTFLVFMSHGIQEGICGTTYSNEVSDILKVDTIFQMMNTLKCPSLKDKPKVIIIQACRGEKQGVVLLKDSVRDSEEDFLTDAIFEDDGIKKAHIEKDFIAFCSSTPDNVSWRHPVRGSLFIESLIKHMKEYAWSCDLEDIFRKVRFSFEQPEFRLQMPTADRVTLTKRFYLFPGH
  
Inhibitor
Name:
BDBM50072048
Synonyms:
CHEMBL92017 | [(3R,6S,8aS)-3-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-5-oxo-hexahydro-thiazolo[3,2-a]pyridin-6-yl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C20H23N3O7S
Mol. Mass.:
449.478
SMILES:
OC1OC(=O)C[C@@H]1NC(=O)[C@@H]1CS[C@H]2CC[C@H](NC(=O)OCc3ccccc3)C(=O)N12
Structure:
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