Reaction Details Report a problem with these data
Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50528640
Substrate
n/a
Meas. Tech.
ChEMBL_1905929 (CHEMBL4408287)
IC50
480±n/a nM
Citation
 Romagnoli, R; Oliva, P; Salvador, MK; Camacho, ME; Padroni, C; Brancale, A; Ferla, S; Hamel, E; Ronca, R; Grillo, E; Bortolozzi, R; Rruga, F; Mariotto, E; Viola, G Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors. Eur J Med Chem 181:0 (2019) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50528640
Synonyms:
CHEMBL4551856
Type:
Small organic molecule
Emp. Form.:
C19H19FN2O3
Mol. Mass.:
342.3642
SMILES:
COc1cc(cc(OC)c1OC)-c1n[nH]cc1-c1ccc(C)c(F)c1
Structure:
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