Reaction Details Report a problem with these data
Target
Similar to alpha-tubulin isoform 1
Ligand
BDBM50528644
Substrate
n/a
Meas. Tech.
ChEMBL_1905929 (CHEMBL4408287)
IC50
480±n/a nM
Citation
 Romagnoli, R; Oliva, P; Salvador, MK; Camacho, ME; Padroni, C; Brancale, A; Ferla, S; Hamel, E; Ronca, R; Grillo, E; Bortolozzi, R; Rruga, F; Mariotto, E; Viola, G Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors. Eur J Med Chem 181:0 (2019) [PubMed]  Article 
Target
Name:
Similar to alpha-tubulin isoform 1
Synonyms:
Similar to alpha-tubulin isoform 1
Type:
PROTEIN
Mol. Mass.:
10383.05
Organism:
Bos taurus
Description:
ChEMBL_104716
Residue:
99
Sequence:
CVSASPSTLARLVSRSAMPAGSSTAWNTAFSPMARCQVTKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRSSSTLSSSSQAKKMP
  
Inhibitor
Name:
BDBM50528644
Synonyms:
CHEMBL4449830
Type:
Small organic molecule
Emp. Form.:
C20H22N2O3S
Mol. Mass.:
370.465
SMILES:
CCSc1ccc(cc1)-c1c[nH]nc1-c1cc(OC)c(OC)c(OC)c1
Structure:
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