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Target
Interleukin-1 receptor antagonist protein
Ligand
BDBM50529330
Substrate
n/a
Meas. Tech.
ChEMBL_1908435 (CHEMBL4410793)
Ki
1300±n/a nM
Citation
 Tsoukalidou, S; Kakou, M; Mavridis, I; Koumantou, D; Calderone, V; Fragai, M; Stratikos, E; Papakyriakou, A; Vourloumis, D Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases. Bioorg Med Chem 27:0 (2019) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor antagonist protein
Synonyms:
ICIL-1RA | IL-1RN | IL-1ra | IL1 inhibitor | IL1F3 | IL1RA | IL1RA_HUMAN | IL1RN | INN=Anakinra | IRAP | Interleukin-1 receptor antagonist protein
Type:
PROTEIN
Mol. Mass.:
20053.78
Organism:
Homo sapiens
Description:
ChEMBL_118941
Residue:
177
Sequence:
MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
  
Inhibitor
Name:
BDBM50529330
Synonyms:
CHEMBL4527760
Type:
Small organic molecule
Emp. Form.:
C31H35N5O4
Mol. Mass.:
541.6407
SMILES:
CCCC[C@H](N)C(=O)NNc1ccc(cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1 |r|
Structure:
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