Reaction Details Report a problem with these data
Target
Presenilin-1
Ligand
BDBM50534358
Substrate
n/a
Meas. Tech.
ChEMBL_1928521 (CHEMBL4431697)
EC50
10.0±n/a nM
Citation
 Bursavich, MG; Harrison, BA; Blain, JF Gamma Secretase Modulators: New Alzheimer's Drugs on the Horizon? J Med Chem 59:7389-409 (2016) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50534358
Synonyms:
CHEMBL4435318
Type:
Small organic molecule
Emp. Form.:
C25H25ClFN5O2
Mol. Mass.:
481.95
SMILES:
CCn1cc(C(C)N2[C@H](C)Cn3c(ccc(-n4cnc(C)c4)c3=O)C2=O)c2cc(Cl)c(F)cc12 |r|
Structure:
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